A moment of great change sparks the friendship of a lifetime.... Iowa, 1967. Nursing school roommates BettyKay and Kitty don't have much in common. A farmer's daughter, BettyKay has risked her family's disapproval to make her dreams come true away from her small rural town. Cosmopolitan Kitty has always relied on her beauty and smarts to get by and to hide a devastating secret from the past that she can't seem to outrun. Yet the two share a determination to prove themselves in a changing world, forging an unlikely, powerful bond on a campus unkind to women. Before their first year is up, tragedy strikes, and the women's paths are forced apart. But against all odds, a decades-long friendship forms, persevering through love, marriage, failure, and death, from the jungles of Vietnam to the glamorous circles of Hollywood. Until one snowy night leads their relationship to the ultimate crossroads. Fifty years later, two estranged sisters are shocked when a famous movie star shows up at their mother's funeral. Over one tumultuous weekend, the women must reckon with a dazzling truth about their family that will alter their lives forever...